Job Information
US Tech Solutions In-vitro Scientist II in South San Francisco, California
General Position Summary/Purpose:
The DMPK-BA department is seeking a highly motivated fulltime DMPK Scientist to join the In Vitro ADME Sciences group (IVAS).
The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and also may work on other in vitro ADME assays. DMPK-BA works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies , support clinical evaluation and contribute to IND and NDA filings.
In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays primarily including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes.
Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.
Core Job Responsibilities:
Routinely conduct (hands-on) evaluation of CYP450 induction
Conduct qPCR assay
Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
Perform human hepatocytes cell culture, seeding and maintenance
Perform cell viability assessments and use microplate reader to measure endpoint
Contribute to invitro ADME assay design and discussions
Analyze data and maintain detailed, accurate and comprehensible study documentations
Use BioELN and GraphPad Prism for data analysis
BS or MS in with 3-5 + (BS) Ph.D. with 0+ years with relevant exp. In their PhD program (Chemistry/Bio Chemistry)
Top 5 skills
CYP induction assay
in vitro ADME
qPCR
Cell culture
liquid handling system
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.