Job Information
Actalent Senior Scientist Upstream Process Development in Oklahoma City, Oklahoma
Job Title: Senior ScientistJob Description
We are seeking a highly skilled Senior Scientist responsible for leading and overseeing multiple client projects in parallel. The ideal candidate will design, plan, and execute experimental protocols using shake-flasks, high throughput bioreactor systems (ambr15/ ambr250), and bench-top small scale bioreactors to optimize upstream cell culture process performance for manufacturing a variety of biologics such as mAb and therapeutic recombinant proteins. This role involves independently optimizing and developing robust and scalable bioprocess platforms primarily fed-batch and perfusion systems, driving innovation by scouting, assessing, developing, and implementing new technology platforms.
Responsibilities
Lead and oversee multiple client projects in parallel.
Design, plan, and execute experimental protocols using various bioreactor systems to optimize upstream cell culture process performance.
Independently optimize and develop robust and scalable bioprocess platforms primarily fed-batch and perfusion systems.
Drive innovation by scouting, assessing, developing, and implementing new technology platforms such as PAT, process control, culture media, and feed media optimization.
Support additional R&D Services teams by generating, reviewing, and interpreting USP results.
Support Manufacturing groups by leveraging cell culture expertise to support investigations and troubleshoot complex technical challenges.
Essential Skills
Ph.D. in Bioprocess or Biochemical Engineering with at least 7 years of relevant experience, including more than 3 years of USP industrial experience, or M.Sc. with at least 10 years of relevant experience, including more than 2 years of USP industrial experience.
Proven track record and expertise in high throughput process characterization and optimization techniques and tools (e.g., DoE, statistical analysis, QbD).
Proven track record of developing, optimizing, and scaling up Continuous Perfusion and Fed-batch systems.
Proven expertise in upstream process scale-up and scale-down to support commercialization.
Proficient in designing and operating high throughput experiments using ambr15/ambr250.
Willingness to relocate to OKC.
Strong written and oral communication skills.
Ability to communicate technical details of projects and project strategy to clients and team members.
Ability to work independently and exercise good judgment based on experimental data.
Additional Skills & Qualifications
Ability to read, analyze, and interpret common scientific and technical journals, financial reports, and legal documents.
Ability to respond to common inquiries or complaints from customers, regulatory agencies, or members of the business community.
Proficient in technical writing and verbal communication to present updates to clients, top management, public groups, and/or boards of directors.
Ability to define problems, collect data, establish facts, and draw valid conclusions.
Ability to interpret an extensive variety of technical instructions in mathematical or diagram form and deal with several abstract and concrete variables.
Good working knowledge of regulatory agencies and guidance documents governing GMP manufacturing such as ICH, FDA, and EMA is preferred.
CDMO experience within bioprocess development is highly preferred.
Work Environment
The work environment is dynamic and collaborative, focusing on cutting-edge bioprocess development. The role involves working with advanced bioreactor systems and requires a strong understanding of regulatory guidelines. The position is based in OKC, and relocation is required. The candidate will be part of a team that values innovation and excellence in bioprocess development.
Pay and Benefits
The pay range for this position is $75000.00 - $140000.00/yr.
The USP Sr. Scientist leads multiple client projects to meet timeline, budget and scope commitments and has good working knowledge of cell culture development pertaining to drug development. The Scientist has a proficient working knowledge of all relevant disciplines pertaining to the drug development process and knowledge of relevant business elements. She/He keeps an up-to-date awareness of advances in multiple technological and scientific areas and has strong academic and industrial network. He/She may supervise and mentor other colleagues by providing guidance, coaching, and career development support.
Workplace Type
This is a fully onsite position in Oklahoma City,OK.
Application Deadline
This position is anticipated to close on Mar 28, 2025.
About Actalent
Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.
Diversity, Equity & Inclusion
At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I are embedded into our culture through:
Hiring diverse talent
Maintaining an inclusive environment through persistent self-reflection
Building a culture of care, engagement, and recognition with clear outcomes
Ensuring growth opportunities for our people
The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.
If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com (%20actalentaccommodation@actalentservices.com) for other accommodation options.