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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

AbbVie is recruiting for a Scientist II / Sr. Scientist I, Drug Substance Purification Development position in the Department of Neurotoxin & Biologics Process Sciences (NBPS), at its Irvine, CA site.

Position Description:

The Scientist II / Sr. Scientist I, Drug Substance Process Development, will be an instrumental team member of the NBPS group. The primary function of this position is to perform drug substance downstream/purification process development and optimization studies for natural and recombinant proteins (including neurotoxins) from bacterial cultures.

The desired candidate will have a good understanding of purification concepts and methodology and hands-on work experience with biologics purification process development, including process chromatography, ultrafiltration/diafiltration, process characterization and optimization, process scale up, scale down model qualifications and validation. The successful candidate will perform laboratory work, develop productive collaborations and communications with other groups across scientific disciplines and be motivated to innovate and succeed in a fast-paced, collaborative environment.

Key Responsibilities:

• Hands on laboratory bench work to develop and prepare biologics products candidates for various groups with tight timelines.

• Perform and support design and execution of experiments for drug substance purification process.

• Follow study protocols or batch records and execute experiments independently (or minimal supervision) at small and large scales.

• Independently operate and have sound knowledge of TFF system and AKTA chromatography skid systems. Position requires proficient knowledge and hands on experience of clarification equipment as well.

• Routine down-stream purification operations relating to AKTA chromatography system prep: system set-up, assembly/disassembly, system clean-up, in process sampling, buffer preparation, and ability to troubleshoot operational and equipment issues

• Must be willing to work with and handle potent neurotoxins and in-process samples that contain neurotoxin and neurotoxin expressing organisms. Learn and develop a safety mindset and adhere to safety procedures regarding neurotoxin handling. Ability to perform all operations and manipulation under a biosafety laminar flow hood.

• Maintain all required trainings, support safety programs and ensure safety in all routine and new operations.

• Communicate and work closely with members from different teams within process development and analytical development groups to foster a collaborative environment for advancement of projects.

• Additional responsibilities include data analysis, troubleshooting process and equipment, participation in project teams, lab inventory and organization, maintaining detailed records of batches and experiments.

Qualifications

• BS, MS, or PhD in Pharmaceutical Sciences, Microbiology, Biochemistry, Biochemical/chemical engineering, or closely related field.

• Scientist II minimally requires a Master’s degree with 5 years, or Bachelor’s degree with 7 years of relevant industry experience.

• Sr. Scientist I typically requires a PhD (no additional experience required), Master’s degree with 8 years, or Bachelor’s degree with 10 years of relevant experience.

• The ability to demonstrate a significant level of hands-on experience in biologics purification process development such as process chromatography, ultrafiltration/diafiltration, process characterization and optimization, process scale up, scale down model qualifications and validation.

• Must have extensive knowledge of protein chemistry, chromatography, and purification principles

• Hands-on experience in the operation of TFF and purification AKTA chromatography system is required.

• Must demonstrate technical proficiency, scientific creativity, independent thought, and motivation to drive continuous improvement.

• Proven ability to work independently, effectively plan and organize work activities, and prioritize task completion to meet project deadlines in a fast-paced environment is required.

• Must have a team-centric mindset in order to integrate seamlessly in a team setting when working/collaborating with other members within the group and with other groups.

• Excellent oral and written communication skills is required as is experience with documentation of experimental plans, analyzing data and generating high quality technical reports.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.