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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Lilly Small Molecule Discovery group is an organization purpose-built to create molecules that make life better for people. We focus on using cutting edge science to unlock new approaches that can treat people suffering from diseases with poor treatment options. We continually challenge ourselves to deliver molecules that can provide breakthrough efficacy with the highest possible safety margins. We are dedicated to optimizing our mindset, technology, and processes for faster, more nimble execution. Our success is built on a culture that empowers innovative problem solving through open collaboration and individual accountability.

Position Summary:

Lilly’s Early Molecule Discovery team is responsible for small molecule hit to lead prosecution using traditional, and where warranted, novel mechanisms and technologies on early pre-portfolio targets. We seek an experienced drug hunting leader with expertise in biophysics and mass spectrometry to lead a cross-functional team in characterizing protein/ligand, protein/protein, and protein/partner interactions. This will be accomplished through state-of-the-art biophysical tools to guide the selection of chemical matter best suited for the target product profile. The role also includes leading a thoughtful, and comprehensive, MS-based cell and enzyme characterization to evaluate protein proximity, dynamics, and interactomics.

The position requires an individual who can lead coordinated efforts application of these techniques across multiple programs and modalities simultaneously. Maintaining an extensive understanding of current state-of-the-art technologies and building novel capabilities within the group to deliver meaningful data for our project teams is essential. Collaboration is critical in this role; thus, the candidate must work closely with teams.

Responsibilities:

· Lead both internal and external teams toward identification, elaboration, and characterization of early lead molecules across multiple projects and mechanisms

· Direct the deployment of biophysics resources to rapidly interrogate hit chemical matter for kinetics, protein binding effects, proximity induction, or other common biophysics bases analysis.

· Deploy HDX MS teams to navigate novel binding locations and effects on protein dynamics and/or protein/protein interactions.

· Actively engage in defining overall functional area strategy and priorities to meet timeline expectations.

· Catalyze new hit and lead characterization with state-of-the-art cell and enzyme based MS chemical biology characterization.

· Collaboratively evaluate and develop MS and Biophysics based screening capabilities when needed.

· Proactively identify and pursue novel techniques and technologies to improve the identification/optimization of ligands across multiple inhibition mechanisms.

· Continually ensure team has quality state of the art tools and equipment to enable workflows.

· Actively engage in defining Early Molecule Discovery strategy and priorities.

· Ensure the timely delivery of robust, rigorous, data to project teams which enables rapid chemical series evaluation

· To be adept at communicating team expectations and setting team and help to craft larger organizational goals.

Basic Requirements:

· PhD with minimum of 15+ years academic/research/industry exp (may include post-doc experience) OR MS with 15+ years industry/academic/research exp BS with 25+ years industry/academic/research experience.

Additional Preferences:

· Ability to create, sustain and model culture of innovation, collaboration, and dedication

· History of successful drug discovery

· Demonstrated experience in working collaboratively across various disciplines to meet project goals and timelines.

· Flexibility to adjust priorities over time to meet organizational and scientific goals.

· Ability to work independently and as an integral part of a larger collaborative team.

· Continual Learner

· Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.

· Views personal success is a consequence of team’s success.

· Self-accountable for the timely delivery of progressable leads to the larger organization

· Self driven, hardworking, lab first, data dependent decision maker

· Ability to anticipate key challenges and proactively propose solutions.

· Adaptive to changes and apply creative problem-solving skill to meet project and other operational needs.

· Ability to lead with a high level of team empowerment and buy-in

Additional Information:

This position can be based at Indianapolis, IN, Louisville, CO, or San Diego, CA site.

Physical Demands/Travel:

The physical demands of this job are consistent with a lab environment.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

This position requires travel 20% of the time

Work Environment:

This position’s work environment is in a Laboratory.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$171,000 - $332,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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